What is SLU-PP-332?
SLU-PP-332 is a synthetic small molecule supplied as a reference standard for laboratory research. It is not a peptide, and it is handled, stored and prepared differently from the rest of the catalogue.
Compound class
It is a synthetic agonist of the oestrogen related receptors, a family of orphan nuclear receptors. It was first described in the academic literature by a research group at Saint Louis University, and the designation SLU-PP-332 is that group’s internal compound code rather than a trade name or an international non-proprietary name.
Where the evidence stands
The published work on this compound is preclinical and the volume of it is small. It appears in cell based and rodent studies of nuclear receptor signalling and mitochondrial metabolism. There is no human data, no clinical development programme and no independent replication at the scale that would let a researcher treat any of the published findings as settled.
Investigators should read the primary literature directly. Secondary summaries of this compound in circulation overstate what the source papers actually report.
Specification figures for SLU-PP-332
The molecular formula, molecular weight and CAS number for the lot supplied are stated on its certificate of analysis. Published figures for research compounds are not always consistent between sources, so this page defers to the certificate rather than restating a value that may not match the material in the vial.
Small molecule handling differs from peptide handling
This compound is not appreciably water soluble. Stock solutions are normally prepared in an organic solvent such as DMSO rather than in water or aqueous buffer, and the working solution is then diluted into the assay medium with attention to the final solvent concentration and to any vehicle effect in the control arm.
Purity is assessed by HPLC with UV detection and identity is confirmed by mass spectrometry. The analytical approach is comparable to the peptide catalogue but the acceptance criteria and the impurity profile are not, so read the certificate for this compound on its own terms.
Analysis and certification
Each lot of SLU-PP-332 is analysed by an independent laboratory before it is released for sale. The certificate of analysis is published against the lot number rather than the product page, so the document you read is the document for the vial you receive.
Research use only
NH Peptides supplies SLU-PP-332 as an analytical reference standard for laboratory research. It is not supplied for any use in humans or animals, and no information on this page describes or implies any such use.
| Compound |
SLU-PP-332 |
| Class |
Synthetic small molecule. Not a peptide |
| CAS number |
Stated on the certificate of analysis |
| Molecular formula |
Stated on the certificate of analysis |
| Molecular weight |
Stated on the certificate of analysis |
| Appearance |
Solid, colour stated on the certificate of analysis |
| Purity specification |
≥98% |
| Identity method |
Mass spectrometry |
| Purity method |
HPLC with UV detection |
| Solubility |
Not appreciably water soluble. Organic solvent required for stock preparation |
| Labelled quantity |
5mg, stated on the vial label |
How SLU-PP-332 is tested
Two separate analyses are carried out on every lot before it is released, and both appear on the certificate. Identity is confirmed by mass spectrometry against the expected mass. Purity is determined by HPLC with UV detection.
The purity specification for this compound is lower than the ≥99% applied to the peptide catalogue. That is a difference in what is achievable and expected for a synthetic small molecule of this type, not a difference in how the material is assessed.
Purity specification for SLU-PP-332
Lots are released against a ≥98% purity specification, determined by HPLC peak area. The figure for the lot you receive is stated on its certificate of analysis and may differ from the specification.
A specification is a release threshold, not a description of every lot. Where a measured figure and the specification differ, the certificate is the record that applies to your material. Analytical figures relate to the lot they are published against and carry no implication of suitability for any purpose beyond laboratory research.
Storing SLU-PP-332
Store the sealed vial dry at −20°C or below, protected from light and moisture. Allow it to reach room temperature before breaking the seal, so that moisture does not condense onto the solid.
Preparing stock solutions
This compound is not appreciably water soluble and will not reconstitute in water or aqueous buffer in the way the peptide catalogue does. Prepare stock solutions in an appropriate organic solvent, typically DMSO, and confirm solubility against the certificate of analysis before preparing stocks.
Dilute the stock into assay medium immediately before use, keeping the final solvent concentration within the tolerance of your cell system and matching it in the vehicle control. Solvent effects are a common confounder in small molecule work and are worth controlling explicitly.
Hold stocks at −20°C in tightly sealed, solvent compatible vials. DMSO is hygroscopic and absorbed water will change the effective concentration of a stock over time, so aliquot on preparation and avoid repeated opening of a single tube.
Handling and disposal
Assess the hazards of this material before handling and use appropriate controls and protective equipment. It has not been characterised toxicologically and should be treated as potentially hazardous. Note that DMSO carries dissolved solutes across skin, so solvent stocks require more care in handling than the dry solid.
Record the lot number from the vial label in your own inventory alongside the certificate of analysis, storage temperature and disposal route, so that your records remain auditable after the order closes.
Dispose of unused material, solvent stocks, vials and packaging lawfully and in line with your institution’s waste procedures. Solvent containing waste goes to the appropriate chemical waste stream. Do not dispose to drain.